Objective: To investigate the possible mechanism of Yiqing
Capsules in the treatment of upper respiratory tract infection based on network
pharmacology. Methods: The main active components of Yiqing Capsules were
selected on TCMSP database; the targets of upper respiratory tract infection were
selected on GeneCards database. The drug-compound-target network and PPi network
were constructed through STRING database and soft Cytoscape 3.7.2. Soft R was used
to perform GO enrichment analysis and KEGG pathway enrichment analysis of main targets. Results: According to the screening conditions, 48 active compounds and
171 related targets were obtained. GO enrichment analysis obtained 2333 items,
KEGG pathway enrichment analysis obtained 2248
items, including Kaposi sarcoma-associated herpesvirus infection, Human cytomegalovirus
infection, Epstein-Barr virus infection, PI3K-Akt signaling pathway, etc. Conclusion:
Yiqing capsules play a therapeutic role in upper respiratory tract infection
through multi-target and multi-pathway.
References
[1]
Ding, H., Yan, B., Tian, L., et al. (2011) A Mutli-Center Randomized Double-Blind Controlled Trial on the Function of Yiqing Capsule Treat. Liaoning Journal of Traditional Chinese Medicine, 38, 1468-1490.
[2]
Liu, X. (2017) Study on the Effect of Chronic Pharyngitis Mixture on Chronic Pharyngitis. Medical Innovation of China, 14, 112-114.
[3]
Zhang, Y. and Wang, Y. (2016) Observation of Yiqing Capsule Combined with Antibiotic in the Treatment of 118 Cases of Acute Pharyngitis. Nei Mongol Journal of Traditional Chinese Medicine, 2, 74-75.
[4]
Zhang, L. (2018) Analysis of the Efficacy of Yiqing Capsule Combined with Meifeng in Treating Chronic Pharyngitis. Clinical Research, 26, 118-120.
[5]
Jiang, R. and Zhang, C. (2010) Clinical Observat Ion on 72 Cases of Acne Vulgaris Treated by Yiqing Capsule. Journal of Traditional Chinese Medicine, 51, 996-998.
[6]
Liu, C., Xie, B., Cai, L., et al. (2018) Clinical Study on Yiqing Capsules Combined with Minocycline in Treatment of Chronic Periodontitis. Drugs & Clinic, 33, 2083-2086.
[7]
Hou, Y., Liu, X. and Xu, Q. (2001) Clinical Observation of 156 Cases of Acute Upper Respiratory Tract Infection Treated by Yiqing Capsule and Antibiotics. West China Journal of Pharmaceutical Sciences, 16, 401.
[8]
Liu, W. (2018) Levels and Clinical Significances of Serum 25-Hydroxyvitamin D3, IL-10 and IL-17 in Children with Recurrent Upper Respiratory Infection. China Medical Herald, 15, 80-83.
