There
are limited studies examining the relationship between serum reproductive
hormone levels and sexual functions among prostate cancer (PCa) patients after
rapid prostatectomy (RP). Aim: The present study aimed at evaluating the
correlation between post-operative serum levels of some male reproductive
hormones of PCa patients and their sexual functions in the months following RP.A total
of 20 male patients with clinically localized PCa who had undergone RP within
the last 12 months prior to commencement of the study, were invited to
participate.Thepostoperative serum levels of their luteinizing hormone (LH), follicle
stimulating hormone (FSH) and total testosterone (Te) were measured. They also
completed a structured health and lifestyle questionnaire to obtain information
on their demographic characteristics and detailed medical history.Our
data indicated normal mean levels of post-operative Te (4.34 ± 4.38 ng/ml) in
the patients following RP, while the mean levels of FSH (39.24 ± 34.12 miu/ml)
and LH (21.67 ± 25.73 miu/ml) were on the increase and far above normal ranges
for healthy men. Data indicated a significant positive correlation between Te
and frequency of sexual intercourse (r = 508; p < 0.05), libido (r = 0.429;
p < 0.05) and penile erection (r = 0.494; p < 0.05). However, no
significant correlations were found between FSH or LH and any of the sexual
function parameters.The present study indicated that radical prostatectomy affected
reproductive hormones by increasing LH and FSH concentrations above normal
ranges for healthy men, while Te
References
[1]
Bray, F., Ferlay, J., Soerjomataram, I., Siegel, R.L., Torre, L.A. and Jemal, A. (2018) Global Cancer Statistics 2018: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA: A Cancer Journal for Clinicians, 68, 394-424. https://doi.org/10.3322/caac.21492
[2]
Ferlay, J.E.M., Lam, F., Colombet, M., Mery, L., Pineros, M., Znaor, A., Soerjomataram, I., et al. (2020) Global Cancer Observatory: Cancer Today. International Agency for Research on Cancer, Lyon. https://gco.iarc.fr/today
[3]
Hyun, J.S. (2012) Prostate Cancer and Sexual Function. The World Journal of Men’s Health, 30, 99-107. https://doi.org/10.5534/wjmh.2012.30.2.99
[4]
Moore, T.M., Strauss, J.L., Herman, S. and Donatucci, C.F. (2003) Erectile Dysfunction in Early, Middle, and Late Adulthood: Symptom Patterns and Psychosocial Correlates. Journal of Sex & Marital Therapy, 29, 381-997. https://doi.org/10.1080/00926230390224756
[5]
Nelson, C.J., Mulhall, J.P. and Roth, A.J. (2011) The Association between Erectile Dysfunction and Depressive Symptoms in Men Treated for Prostate Cancer. The Journal of Sexual Medicine, 8, 560-566. https://doi.org/10.1111/j.1743-6109.2010.02127.x
[6]
Signy, H. (Ed.) (2014) Understanding Sexual Issues Following Prostate Cancer Treatment. Prostate Cancer Foundation of Australia. http://www.prostate.org.au/media/468674/understanding-sexual-issues.pdf
[7]
McCullough, A.R. (2005) Sexual Dysfunction after Radical Prostatectomy. Reviews in Urology, 7, S3-S10.
[8]
Madersbacher, S., Schatzl, G., Bieglmayer, C., et al. (2002) Impact of Radical Prostatectomy and TURP on the Hypothalamic-Pituitary-Gonadal Hormone Axis. Urology, 60, 869-874. https://doi.org/10.1016/S0090-4295(02)01893-9
[9]
Miller, L.R., Partin, A.W., Chan, D.W., et al. (1998) Influence of Radical Prostatectomy on Serum Hormone Levels. Journal of Urology, 160, 449-453. https://doi.org/10.1016/S0022-5347(01)62922-7
[10]
Reiter, R.E. and de Kernion, J.B. (2002) Epidemiology, Etiology, and Prevention of Prostate Cancer. In: Walsh, P.C., Ed., Campbell’s Urology, 8th Edition, Saunders, Philadelphia, 3003.
[11]
Massengill, J.C., Sun, L., Moul, J.W., Wu, H., McLeod, D.G., Amling, C., et al. (2003) Pretreatment Total Testosterone Level Predicts Pathological Stage in Patients with Localized Prostate Cancer Treated with Radical Prostatectomy. Journal of Urology, 169, 1670-1676. https://doi.org/10.1097/01.ju.0000062674.43964.d0
[12]
Morgentaler, A., Bruning 3rd, C.O. and DeWolf, W.C. (1996) Occult Prostate Cancer in Men with Low Serum Testosterone Levels. JAMA, 276, 1904-1906. https://doi.org/10.1001/jama.1996.03540230054035
[13]
Yamamoto, S., Yonese, J., Kawakami, S., Ohkubo, Y., Tatokoro, M., et al. (2007) Preoperative Serum Testosterone Levels as an Independent Predictor of Treatment Failure Following Radical Prostatectomy. European Urology, 52, 696-701. https://doi.org/10.1016/j.eururo.2007.03.052
[14]
Khera, M. (2009) Androgens and Erectile Function: A Case for Early Androgen Use in Postprostatectomy Hypogonadal Men. Journal of Sexual Medicine, 6, 234-238. https://doi.org/10.1111/j.1743-6109.2008.01159.x
[15]
Corradi, P.F., Corradi, R.B. and Greene, L.W. (2016) Physiology of the Hypothalamic Pituitary Gonadal Axis in the Male. Urologic Clinics of North America, 43, 151-162. https://doi.org/10.1016/j.ucl.2016.01.001
[16]
Zung, W.W. (1965) A Self-Rating Depression Scale. Archives of General Psychiatry, 12, 63-70. https://doi.org/10.1001/archpsyc.1965.01720310065008
[17]
Griffin, J.E. and Wilson, J.D. (1998) Disorders of the Testes. In: Fauci, A.S., Martin, J.B., Braunwald, E., Kaspar, D.L., Isselbacher, K.J. and Hauser, S.I., Eds., Harrison’s Principles of Internal Medicine, McGraw-Hill, New York, 2087-2097.
[18]
Schmitt, C.S., Rhoden, E.L. and Almeida, G.L. (2011) Serum Levels of Hypothalamic-Pituitary-Testicular Axis Hormones in Men with or without Prostate Cancer or Atypical Small Acinar Proliferation. Clinics, 66, 183-187. https://doi.org/10.1590/S1807-59322011000200001
[19]
Namiki, S., Mitsuzuka, K., Kaiho, Y., Yamada, S., Adachi, H., Yamashita, S., Saito, H., Ito, A., Nakagawa, H., Takegami, M. and Ara, Y. (2016) Serum Luteinizing Hormone Concentration Is Significantly Associated with Recovery of Urinary Function after Radical Prostatectomy. BJU International, 117, 450-455. https://doi.org/10.1111/bju.13083
[20]
Gacci, M., Tosi, N., Vittori, G., Minervini, A., Corona, G., Cai, T., Morelli, A.M., Vignozzi, L., Serni, S., Maggi, M. and Carini, M. (2013) Changes in Sex Hormone Levels after Radical Prostatectomy: Results of a Longitudinal Cohort Study. Oncology Letters, 6, 529-533. https://doi.org/10.3892/ol.2013.1420
[21]
Tsitouras, P.D., Martin, C.E. and Harman, S.M. (1982) Relationship of Serum Testosterone to Sexual Activity in Healthy Elderly Men. Journal of Gerontology, 37, 288-293. https://doi.org/10.1093/geronj/37.3.288
[22]
Gades, N.M., Jacobson, D.J., McGree, M.E., et al. (2008) The Associations between Serum Sex Hormones, Erectile Function, and Sex Drive: The Olmsted County Study of Urinary Symptoms and Health Status among Men. Journal of Sexual Medicine, 5, 2209-2220. https://doi.org/10.1111/j.1743-6109.2008.00924.x
[23]
O’Connor, D.B., Lee, D.M., Corona, G., et al. (2011) The Relationships between Sex Hormones and Sexual Function in Middle-Aged and Older European Men. The Journal of Clinical Endocrinology & Metabolism, 96, E1577-E1587.
[24]
Marberger, M., Wilson, T.H. and Rittmaster, R.S. (2011) Low Serum Testosterone Levels Are Poor Predictors of Sexual Dysfunction. BJU International, 108, 256-262. https://doi.org/10.1111/j.1464-410X.2010.09766.x
[25]
Hoppe, B.S., Nichols, R.C., Henderson, R.H., Morris, C.G., Williams, C.R., Costa, J., et al. (2012) Erectile Function, Incontinence, and Other Quality of Life Outcomes Following Proton Therapy for Prostate Cancer in Men 60 Years Old and Younger. Cancer, 118, 4619-4626. https://doi.org/10.1002/cncr.27398
[26]
Helgason, A.R., Adolfsson, J., Dickman, P., Fredrikson, M., Arver, S. and Steineck, G. (1996) Waning Sexual Function—The Most Important Disease-Specific Distress for Patients with Prostate Cancer. British Journal of Cancer, 73, 1417-1421. https://doi.org/10.1038/bjc.1996.268
[27]
Lackner, J.E., Maerk, I., Koller, A., et al. (2008) Serum Inhibin—Not a Cause of Low Testosterone Levels in Hypogonadal Prostate Cancer? Urology, 72, 1121-1124. https://doi.org/10.1016/j.urology.2008.01.066
