Te signifcance of sTREM-1 as a diagnostic biomarker of sepsis in the context of Sepsis-3 definition

Sa？etak Aim. Sepsis remains the leading cause of mortality in spite of advanced diagnostics. Te aim of the study was to test the diagnostic value of soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) in the context of a new defnition of sepsis. Methods. Te study was conducted on 41 patients who were suspected of having sepsis according to SIRS (Systemic Infammatory Response Syndrome) criteria or sterile SIRS. 20 healthy volunteer blood donors were the control group (adult patients of both sexes). According to the latest sepsis criteria (Sepsis-3), patients were retrospectively divided into three subgroups: septic patients, patients with SIRS plus infection and patients with sterile SIRS (non-infectious SIRS). All subjects had concentrations of sTREM-1 determined by the ELISA method (Abcam commercial test, Cambridge, MA, USA). Samples were collected upon admission to hospital and kept at -20°C until laboratory analysis was performed. Results. Concentrations of sTREM-1 were signifcantly increased in patients, compared to the healthy population (p=0.021), but there were no signifcant diferences among subgroups of patients (SIRS plus infection vs. sepsis p=0.871, SIRS plus infection vs. sterile SIRS p=0.72, sepsis vs. sterile SIRS p=0.65). Te value of 300pg/mL was determined to be the optimal cut-of. Concentrations of sTREM-1 were signifcantly higher in septic patients who did not develop Multiple Organ Dysfunction Syndrome (MODS) within the frst 48 hours afer admission than in those who did. Conclusion. According to our results, sTREM-1 failed to express signifcance as a diagnostic biomarker of sepsis, according to the new defnition. Also, it seems not to be a valuable marker in diferentiation of sepsis and non-infective SIRS