Background: The novel Coronavirus disease 2019 (COVID-19) has
rapidly evolved into a global emergency with far-reaching consequences.
Multiple models predict mounting morbidity and mortality in the absence of
appropriate interventions. Screening of sub-clinical cases through technological
tools has the potential to eliminate virus containment in the population. Objective: Our aim was to develop an effective application that detected early
COVID-19 infections and resulted in four-dimensional
(4-D) data visualization systems to develop safe networks whilst respecting
user privacy. Methods: We proposed an algorithm for a novel form of contact tracing and
screening that can detect infection before manifestation of clinical symptoms
and signs. We developed a simulation model that demonstrated impact on the
pandemic through percent change in the “trigger
point”. Results: A “trigger point” based on personal risk assessment generated a visual report to the
community network. The following outcomes were rendered in the app: live
surveillance of metadata, hotspot mapping, targeted live health messaging to a
large population, an infection control passport technology, and personal
hotspot avoidance warnings. Our model suggested that higher adoption of such strategies can
potentially eliminate viral carriage in the population. Conclusions: Our proposed technology-enabled screening, detection, and elimination
strategy presents a novel approach to eliminate the viral containment. This app
could be applied to the COVID-19 pandemic as well as other outbreaks and
epidemics in the future to control the unprecedented disease spread.
References
[1]
World Health Organization Coronavirus Disease (COVID-19) Dashboard.
https://covid19.who.int
[2]
World Health Organization (2020) Coronavirus Disease (COVID-19) Outbreak.
https://www.euro.who.int/en/health-topics/health-emergencies/coronavirus-covid-19
[3]
Q&A: How Is COVID-10 Transmitted?
https://www.who.int/emergencies/diseases/novel-coronavirus-2019 /question-and-answers-hub/q-a-how-is-covid-19-transmitted?gclid =EAIaIQobChMIjqWp653F6wlIVV7LVCh1XVQ7ZEAAYASAAEgKbm_D_BwE
[4]
Xiao, F., Tang, M., Zheng, X., Liu, Y., Li, X. and Shan, H. (2020) Evidence for Gastrointestinal Infection of SARS-CoV-2. Gastroenterology, 158, 1831-1833.e3.
https://doi.org/10.1053/j.gastro.2020.02.055
[5]
Team CC-19 R, Centers for Disease Control and Prevention (CDC) COVID-19 Response Team, Bialek, S., Boundy, E., Bowen, V., Chow, N., Cohn, A., Dowling, N., Ellington, S., Gierke, R., et al. (2020) Severe Outcomes among Patients with Coronavirus Disease 2019 (COVID-19)—United States, 12 February-March 16, 2020. Morbidity and Mortality Weekly Report, 69, 343-346.
https://doi.org/10.15585/mmwr.mm6912e2
[6]
Liu, W., Wang, F., Li, G., Wei, Y., Li, X., He, L., Yue, H., Zhang, F., Hu, Q., Chu, J., et al. (2020) Analysis of 2019 Novel Coronavirus Infection and Clinical Characteristics of Outpatients: An Epidemiological Study from the Fever Clinic in Wuhan, China. SSRN Electronic Journal.
[7]
Yang, W., Cao, Q., Qin, L., Wang, X., Cheng, Z., Pan, A., Dai, J., Sun, Q., Zhao, F., Qu, J., et al. (2020) Clinical Characteristics and Imaging Manifestations of the 2019 Novel Coronavirus Disease (COVID-19): A Multi-Center Study in Wenzhou City, Zhejiang, China. Journal of Infection, 80, 388-393.
https://doi.org/10.1016/j.jinf.2020.02.016
[8]
Guan, W.-J., Ni, Z.-Y., Hu, Y., Liang, W.-H., Ou, C.-Q., He, J.-X., Liu, L., Shan, H., Lei, C.-L., Hui, D.S.C., et al. (2020) Clinical Characteristics of Coronavirus Disease 2019 in China. The New England Journal of Medicine, 382, 1708-1720.
https://doi.org/10.1056/NEJMoa2002032
[9]
Yuki, K., Fujiogi, M. and Koutsogiannaki, S. (2020) COVID-19 Pathophysiology: A Review. Clinical Immunology, 215, Article ID: 108427.
https://doi.org/10.1016/j.clim.2020.108427
[10]
Gao, Z., Xu, Y., Sun, C., Wang, X., Guo, Y., Qiu, S. and Ma, K. (2020) A Systematic Review of Asymptomatic Infections with COVID-19. Journal of Microbiology, Immunology and Infection. https://doi.org/10.1016/j.jmii.2020.05.001
[11]
Lao, X., Luo, L., Lei, Z., Fang, T., Chen, Y., Liu, Y., Ding, K., Zhang, D., Wang, R., Zhao, Z., et al. (2019) Epidemiological Characteristics and the Effectiveness of Countermeasures to Control Coronavirus Disease 2019 in Ningbo City, China.
[12]
van Seventer, J.M. and Hochberg, N.S. (2017) Principles of Infectious Diseases: Transmission, Diagnosis, Prevention, and Control. In: International Encyclopedia of Public Health, Elsevier, Boston, 22-39.
https://doi.org/10.1016/B978-0-12-803678-5.00516-6
[13]
Treatments and a Vaccine for COVID-19: The Need for Coordinating Policies on R&D, Manufacturing and Access.
https://www.oecd.org/coronavirus/policy-responses/treatments-and-a-vaccine-for-covid-19-the-need -for-coordinating-policies-on-r-d-manufacturing-and-access-6e7669a9
[14]
Wynants, L., Van Calster, B., Collins, G.S., Riley, R.D., Heinze, G., Schuit, E., Bonten, M.M.J., Damen, J.A.A., Debray, T.P.A., De Vos, M., et al. (2020) Prediction Models for Diagnosis and Prognosis of Covid-19 Infection: Systematic Review and Critical Appraisal. BMJ, 369, m1328. https://doi.org/10.1101/2020.03.24.20041020
[15]
Sharing Research Data and Findings Relevant to the Novel Coronavirus (COVID-19) Outbreak 2020.
https://wellcome.ac.uk/press-release/sharing-research-data-and- findings-relevant-novel-coronavirus-covid-19-outbreak
[16]
COVID-19 and Contact Tracing.
https://extranet.who.int/goarn/sites/default/files/What%20are %20best%20practices%20for%20contact%20tracing%20for% 20COVID19%20SARS%20MERS%20and%20influenza.pdf
[17]
Yu, X. and Yang, R. (2020) COVID-19 Transmission through Asymptomatic Carriers Is a Challenge to Containment. Influenza and Other Respiratory Viruses, 14, 474-475. https://doi.org/10.1111/irv.12743
[18]
de O Lima, C.M.A. and de Oliveira Lima, C.M.A. (2020) Information about the New Coronavirus Disease (COVID-19). Radiologia Brasileira, 53, 5-6.
https://doi.org/10.1590/0100-3984.2020.53.2e1
[19]
Larsen, J.R., Martin, M.R., Martin, J.D., Kuhn, P. and Hicks, J.B. (2020) Modeling the Onset of Symptoms of COVID-19. Frontiers in Public Health.
https://doi.org/10.3389/fpubh.2020.00473
[20]
Caramelo, F., Ferreira, N. and Oliveiros, B. (2020) Estimation of Risk Factors for COVID-19 Mortality—Preliminary Results. Cold Spring Harbor Laboratory Press, Cold Spring Harbor. https://doi.org/10.1101/2020.02.24.20027268
[21]
EPIDEM. http://epideminfo.us
[22]
Budd, J., Miller, B.S., Manning, E.M., Lampos, V., Zhuang, M., Edelstein, M., Rees, G., Emery, V.C., Stevens, M.M., Keegan, N., et al. (2020) Digital Technologies in the Public-Health Response to COVID-19. Nature Medicine, 26, 1183-1192.
https://doi.org/10.1038/s41591-020-1011-4
[23]
Jehi, L., Ji, X., Milinovich, A., Erzurum, S., Rubin, B.P., Gordon, S., Young, J.B. and Kattan, M.W. (2020) Individualizing Risk Prediction for Positive Coronavirus Disease 2019 Testing: Results from 11,672 Patients. Chest, 158, 1364-1375.
https://doi.org/10.1016/j.chest.2020.05.580
[24]
Ministry of Health Singapore (2020) Updates on Covid-19 (Coronavirus Disease 2019) Local Situation. https://www.moh.gov.sg/covid-19
[25]
Latest Situation of Novel Coronavirus Infection in Hong Kong. Centre for Health Protection, Department of Health. The Government of the Hong Kong Special Administrative Region. https://chp-dashboard.geodata.gov.hk/covid-19/en.html
[26]
NHS 111 Online (2020) United Kingdom National Health Services.
https://111.nhs.uk/covid-19
Bonsall, D. and Fraser, C. (2020) Sustainable Containment of COVID-19 Using Smartphones in China: Scientific and Ethical Underpinnings for Implementation of Similar Approaches in Other Settings.
https://int.nyt.com/data/documenthelper/6825-coronavirus-app-proposal-UK/ 76650ed3f249bf888f1e/optimized/full.pdf
[29]
Zastrow, M. (2020) South Korea Is Reporting Intimate Details of COVID-19 Cases: Has It Helped? Nature. https://doi.org/10.1038/d41586-020-00740-y
[30]
Halt to COVID-19 Contact Tracing App a Major Win for Privacy. Amnesty International.
https://www.amnesty.org/en/latest/news/2020/06/norway-covid19-contact-tracing-app-privacy-win
[31]
(2020) Singapore Government Agency Website. TraceTogether.
https://www.tracetogether.gov.sg
[32]
Abeler, J., Bäcker, M., Buermeyer, U. and Zillessen, H. (2020) COVID-19 Contact Tracing and Data Protection Can Go Together. JMIR mHealth and uHealth, 8, e19359.
https://doi.org/10.2196/19359
[33]
Niehus, R., De Salazar, P.M., Taylor, A. and Lipsitch, M. (2020) Quantifying Bias of COVID-19 Prevalence and Severity Estimates in Wuhan, China That Depend on Reported Cases in International Travelers.
[34]
Bhatia, S., Imai, N., Cuomo-Dannenburg, G., Baguelin, M., Boonyasiri, A., Cori, A., Cucunubá, Z., Dorigatti, I., FitzJohn, R., Fu, H., Gaythorpe, K., Ghani, A., Hamlet, A., Hinsley, W., Laydon, D., Nedjati-Gilani, G., Okell, L., Riley, S., Thompson, H., Elsland, S., Volz, E., Wang, H., Wang, Y., Whittaker, C., Xi, X., Donnelly, C. and Ferguson, N. (2020) Report 6: Relative Sensitivity of International Surveillance. Imperial College.
https://www.imperial.ac.uk/mrc-global-infectious-disease-analysis/ covid-19/report-6-international-surveillance/
[35]
Centers for Disease Control and Prevention (2020) Coronavirus Disease 2019 (COVID-19).
https://www.cdc.gov/coronavirus/2019-ncov/need-extra-precautions/people-with-medical-conditions.html
