Preparation, Spectroscopic Characterization and Particle Size Distribution of Sulfamethazine Schiff bases-β-Cyclodextrins Inclusion Complexes

Schiff bases of Sulfamethazine with o.Vanillin and Cinnamaldehyde were prepared and characterized and then the inclusion complexes of thes Schiff bases with β-CD were prepared in 1:1 molar ratio by freeze drying method. The interaction between Schiff bases and β-CD was characterized by IR , HNMR, 13CNMR and XRD. Also, a further study of particle size distribution utilized to investigate the effect of complication on particle size decreased after complication with β-CD.