The Pivotal Role of Transient Receptor Potential (TRP) Ion Channels in the Pathogenesis of Sensitive Skin

Sensitive skin syndrome is a challenging and important condition in the domain of disease management and also in skin care products and cosmetic manufacturing. Conditions like Psoriasis, Rosacea, Contact and Atopic Dermatitis are associated with it. The perception of itch is translated to our brain by neuronal depolarization signals initiated by aberrant Transient Receptor Potential (TRV) Channels; mainly TRPV1, TRPV3, TRPV4 and TRPA1 through a complex inflammatory cascades and mediators. The discovery of these mediators and pathways not only broaden our understanding of the skin-nervous system interaction during the body innate response to adversity but also may provide therapeutic solution to a number of diseases which share similar pathogenesis and aetiology.