摘要 目的 探讨白细胞介素-33（IL-33）及致癌抑制因子2（ST2）蛋白在卵巢癌组织中的表达及其与患者临床病理特征的相关性。 方法 收集青岛大学附属医院妇科2010年1月—2013年12月手术切除卵巢患者的病理标本110例，其中卵巢癌60例，交界性肿瘤28例，良性肿瘤22例。选取20例正常卵巢组织作为正常对照组。采用免疫组织化学方法检测各种组织中IL-33及ST2蛋白的表达，分析其表达与卵巢癌临床病理参数的关系；并分析卵巢癌组织中IL-33与ST2蛋白表达的相关性。 结果 卵巢癌组织、交界性肿瘤组织中IL-33及ST2蛋白的阳性表达率明显高于正常卵巢组织（χ2=7.406～19.710,P＜0.05）；临床Ⅲ～Ⅳ期、低分化卵巢癌组织中IL-33及ST2蛋白的阳性表达率明显高于Ⅰ～Ⅱ期及高分化卵巢癌组织（χ2=3.972～5.319，P＜0.05）；卵巢癌组织中IL-33及ST2蛋白的表达与患者年龄、卵巢癌病理类型及淋巴结转移无关（P＞0.05）；IL-33及ST2蛋白在卵巢癌组织中的表达呈正相关（r=0.577，P＜0.05）。 结论 IL-33及ST2蛋白在卵巢癌组织中高表达，且与卵巢癌的临床病理分期、分化程度有关，IL-33及ST2蛋白可能参与了卵巢癌的发生发展。 Abstract：Objective To investigate the protein expression of interleukin-33 (IL-33) and suppression of tumorigenicity 2 (ST2) in ovarian cancer and their association with clinicopathological features. Methods A total of 110 pathological specimens were collected from the patients who underwent ovariectomy in Department of Gynecology, The Affiliated Hospital of Qingdao University, from January 2010 to December 2013, among which there were 60 specimens of ovarian cancer, 28 specimens of borderline tumor, and 22 specimens of benign tumor. A total of 20 specimens of normal ovarian tissue were selected as normal control group. Immunohistochemistry was used to measure the protein expression of IL-33 and ST2 in each type of tissue, and the association of the expression of IL-33 and ST2 with clinicopathological features of ovarian cancer was analyzed. The correlation between IL-33 and ST2 was also analyzed. Results The positive expression rates of IL-33 and ST2 in ovarian cancer tissue and borderline tumor tissue were significantly higher than those in normal ovarian tissue (χ2=7.406-19.710,P<0.05). Poorly differentiated ovarian cancer tissue with a clinical stage of Ⅲ-Ⅳ had significantly higher positive expression rates of IL-33 and ST2 than the well-differentiated ovarian cancer tissue with a clinical stage of Ⅰ-Ⅱ (χ2=3.972-5.319,P<0.05). In the ovarian cancer tissue, the protein expression of IL-33 and ST2 was not associated with the patient’s age, pathological type of ovarian cancer, and lymph node metastasis (P>0.05). The protein expression of IL-33 was positively correlated with that of ST2 (r=0.577,P<0.05). Conclusion IL-33 and ST2 proteins are highly expressed in ovarian cancer tissue and are associated with the clinicopathological stage and degree of differentiation of ovarian cancer, and they may be involved in the development and progression of ovarian can-cer
