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腺苷调节小胶质细胞极化改善精神分裂症的研究进展
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Abstract:
小胶质细胞作为神经炎症的初始细胞，在中枢神经系统(central nervous system, CNS)免疫中占有重要地位。腺苷是CNS中的重要调节物质，可通过与小胶质细胞中的受体结合发挥作用。有研究表明，小胶质细胞与腺苷结合改变表型，有助于修复损伤的髓鞘，拮抗精神病样症状。本文主要综述腺苷特性、相关分类、小胶质细胞的特性、表型、相关炎症因子以及其与精神分裂症髓鞘修复相关方面的研究进展。为以“小胶质细胞表型”为靶点，开发腺苷系统的新型药物治疗精神分裂症提供参考。
Microglia cells, as the initial cells of neuroinflammation, play an important role in central nervous System (CNS) immunity. Adenosine is an important regulator in CNS, which can play its role by binding to receptors in microglia cells. Studies have shown that the phenotype of microglia cells can be changed by binding to adenosine, which contribute to rebuilding damaged myelin sheath and antagonizing psychotic symptoms. This article made a systemic review on adenosine, including characteristics and classification, and microglia, including characteristics, phenotype, inflammatory cytokines and the relationship between microglia and myelin repair in schizophrenia. This review will greatly enhance our understanding in the pathophysiology of schizophrenia and thus provide new insight into searching for new targets and medications in treating schizophrenia.
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