From (2,3-dihydro-1H-perimidin-2-yl)-phenyl,
the substitution of OH group in ortho or para position on the phenyl ring,
allows us to synthesize the studied compounds. These three compounds have been characterized by conventional
spectroscopic methods (NMR and MS). The interest of this work is to review the
antioxidant activity of our compounds. The antioxidant activity screening carried
out according to FRAP and DPPH methods revealed significant anti-free radical
properties for compounds 1 and 2 even at low concentrations. In contrast to the
compound 2, compound 3 for which the OH group is substituted in para position has the lowest activity in both cases. Therefore the para position seems to be the least
sensitive position to increase the antioxidant activity of this pharmacophore.
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