Cordyceps mycelium extract (Cs-4), Chicken Essence (CE), and their combination were
investigated for antioxidant and immunomodulatory activities in mouse models.
Long-term treatment with Cs-4 or CE at equivalent human doses improved
antioxidant status in various tissues, as evidenced by the enhancement of
mitochondrial glutathione redox status in the brain, liver, heart, and kidney
of mice. Cs-4 or CE treatment also produced an immunomodulatory action, as
indicated by the potentiation of Concanavalin A-/lipopolysaccharide-induced
proliferation of mouse splenocytes ex vivo. While
doubling of the equivalent human doses of Cs-4 and CE did not further enhance
their antioxidant or immunopotentiating effects, the combined treatment with
Cs-4 and CE at their respective equivalent human doses produced an additive
effect, with the extents of stimulation being larger than those produced by
Cs-4 or CE alone. The results have demonstrated for the first time that the
combined use of Cs-4 and CE can produce an additive effect on both
antioxidation and immunopotentiation that cannot otherwise be achieved by
increasing the equivalent human doses of Cs-4 or CE alone.
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