Aconitum kusnezoffii used as an analgesic and anti-inflammatory. It is often used not only in
Mongolian medicine but also in traditional Chinese medicine. However, there are
few studies on its impact of inflammatory cytokines. This study explored the
effects of Aconitum kusnezoffiiin vitro used human colon cancer (Caco-2)
cells. Cytotoxicity was assessed by measuring effects on expression of IL-1β, IL-6, IL-8, and TNF-α used enzyme-linked immunosorbent assay (ELISA). In vitro study demonstrated that incubation of Caco-2 cells with some kinds ofAconitum kusnezoffii at some concentrations
inhibit secretion of TNF-α and FAXIU ACONITUMKUSNEZOFFII could inhibit the secretion of IL-1β.
While IL-6 and IL-8 levels were unaffected after 24 h of treatment with
References
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Zhang, T.Y., Wang, G.J., Liu, S.M. and Zhi, Q. (2008) Application of Aconitum kusnezoffii in Traditional Chinese Medicine and Mongolian Medicine. Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology, 1, 113-116.
[2]
Ling, S. and Gong, Q.F. (2011) Research Progress of Aconitum kusnezoffii. Journal of Jiangxi University of Traditional Chinese Medicine, 3, 90-94.
[3]
Han, Z.Q. and Na, S.S. (2008) Study on the Processing Method of Mongolian Medicine Aconitum kusnezoffii. Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology, 1, 150-154.
[4]
Tong, H.F., Wang, H.L., Han, C.B. and Zhang, Z.L. (2013) Report of 3 Cases of Refractory Arrhythmia Caused by Acute Aconitine Poisoning. Chinese Journal of Evidence-Bases Cardiovascular Medicine, 4, 422.
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Yang, S.J. (2011) Rescue and Nursing Experience of Aconitine Poisoning. Chinese Journal of Disability Medicine, 5, 96.
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Ulijitgus, Liu, Z.B., Wang, H.S., Ding, Y.X. and Su, Y.F. (2008) Effect of Total Alkaloids from Aconitum kusnezoffii Leaves on Immune Function in Mice. Chinese Herbal Medicine, 7, 1064-1065.
[7]
Gao, T.T., Ma, S., Song, J.Y., Bi, H.T. and Tao, Y.D. (2011) Antioxidant and Immunological Activities of Water-Soluble Polysaccharides from Aconitum kusnezoffii reichb. International Journal of Biological Macromolecules, 49, 580-586. https://doi.org/10.1016/j.ijbiomac.2011.06.017
[8]
Gabay, C. (2006) Interleukin-6 and Chronic Inflammation. Arthritis Research and Therapy, 8, Article No. S3. https://doi.org/10.1186/ar1917
[9]
Kakar, S. (2015) Cytokines Evolution: Role in Various Diseases. Current Medicine Research and Practice, 5, 176-182. https://doi.org/10.1016/j.cmrp.2015.07.002
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Van Och, F. M. M., Loveren, H. V., De Jong, W.H., Vandebriel, R. J. (2002) Cytokine Production Induced by Low-Molecular-Weight Chemicals as a Function of the Stimulation Index in a Modified Local Lymph Node Assay: An Approach to Discriminate Contact Sensitizers from Respiratory Sensitizers. Toxicology and Applied Pharmacology, 184, 46-56. https://doi.org/10.1006/taap.2002.9473
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Watanabe, H., Unger, M., Tuvel, B., Wang, B. and Sauder, D. N. (2002) Contact Hypersensitivity: The Mechanism of Immune Responses and T Cell Balance. Journal of Interferon and Cytokine Research, 22, 407-412. https://doi.org/10.1089/10799900252952181
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Xu, X.F., Chen, Y.H., Wang, J., Liao, J.J. and Wu, J.H. (2010) Effects of aconitum scabra on Proliferation, Invasion and Metastasis of Human Lung Cancer A549 Cells and Its Mechanism. Chinese Materia Medica, 12, 1909-1912.
[13]
Han, Z.Q. and batudligan. (2015) Comparative Study on the Processing Effect of Different Texture Mongolian Medicine Aconitum kusnezoffii by Baking Method. Chinese Journal of Clinical Pharmacology, 1, 67-69.
[14]
Kim, J., Kim, S., Lee, S., Jeong, H., Park, M., Kim, D., Song, B., Lee, J. and Kim, S. (2012) Study of Single-Dose Toxicity of Aconitum kusnezoffii Reichb. Pharmacopuncture in Rats. Journal of Pharmacopuncture, 15, 48-52. https://doi.org/10.3831/KPI.2012.15.007
