Clinico-Epidemiological Features and Survival Outcome in Patients with NSCLC: Ain Shams Clinical Oncology Department 5-Year Data

Background: Primary lung cancer is the most common malignant neoplasm worldwide with various prognostic factors. Methods: Data was analysed retrospectively from the medical records of 504 patients diagnosed with NSCLC and treated at Department of Clinical Oncology and Nuclear Medicine, Ain Shams University, Cairo-Egypt in the period from 1-1-2008 till 31-12- 2012. Results: The Median PFS after first, second and third lines was 3, 4 and 2 months respectively and the median OS was 8 months. Factors which were associated with a statistically significant difference in median OS were: age<60 years versus≥60 years (10 and 7 months respectively, p<0.001), female versus male gender (10 and 8 months respectively, p<0.001), urban versus rural residence (9 and 8 months respectively, p=0.03), smokers versus non-smokers (8 and 10 months respectively, p<0.001), patients presenting with non-neurological symptoms and those presenting with neurological symptoms (9 and 6 months respectively, p<0.001) and the receiving treatment versus no treatment (10 and 5 months respectively, p<0.001). Conclusion: This study shows that the active treatment of patients with NSCLC continues to have an important impact on survival. The fact that rural residence could be associated with worse OS warrants further investigation