Morphological Peculiarities of Apoptosis’ Course in Hepatic Cells

The course dynamics of apoptosis in hepatic cells of experimental rabbits (n = 16) and white rats (n = 18) was researched by morphological methods. In natural death (apoptosis) the hepatic cells were divided into two parts. At the first type of apoptosis the hepatocyte’s cytoplasm became clearing, the little vesicles occurred, therefore this type was called as “boiling cytoplasm”. It was more often in rats. The volume of cell increased and became round, the nucleus got peaknotized, and, finally, the apoptotic bodies became formed and eliminated in sinusoids. The second type of apoptosis was characterized with homogenization and acidophilic colour of cytoplasm, the cellular nucleus was decomposed into large conglomerations and kariorexis occurred, so it was marked as “nuclear catastrophe”. At the end of both types the hepatocyte cellular membrane got ruptured, and cytoplasm’s content separated in lumen of vessel. Sometimes old, not being undergone to apoptosis “longliving” hepatocytes became separated from hepatic plates and wholly extrused in lumen of sinusoid. Conclusion: by the cytological course, depending on mainly damage of hepatocyte’ cytoplasm or nucleus two types of apoptosis were divided. Except apoptic death in the liver the extrusion display of “longliving” hepatocytes were revealed