Synthesis, Characterization and Evaluation of Anti-inflammatory Activity of Acetaminophen Complexes of Copper (II) and Zinc (II) Ions

The aim of this research was to synthesize, characterize as well as to investigate the anti-inflammatory properties of Zn (II) and Cu (II) as the central atoms using acetaminophen as the complexing agent. Cu (II) and Zn (II) Complexes were synthesized and characterized by FTIR spectroscopy, UV- Visible Spectroscopy, X-Ray Diffraction Analysis, Melting Point and Conductivity Measurements. On the basis of this study, it is proven that Acetaminophen acts as a bidentate ligand coordinated to the metal ions through phenol and carbonyl oxygen atom. The acute toxic effect was carried out by the method and the rats were found to be moderately toxic and slightly toxic. The test complexes in general showed maximum inhibition percentage at about 3 hours, after 4 hours it goes on reducing and reaches a minimum at about 5 hours.