Analysis of the Levels of Endothelin, Homocysteine and Blood Lipid in Patients with Clinical and Subclinical Hyperthyroidism

[Objective] To discuss the changes of endothelin (ET), homocysteine (Hcy) and blood lipids levels in patients with hyperthyroidism and subclinical hyperthyroidism, and to explore their clinical significance. [Methods] The authors choose 251 cases of hyperthyroidism, 242 cases of subclinical hyperthyroidism and 130 cases of the control group to test ET, Hcy, TC, TG, HDL, LDL and LPa. [Results] The level of ET of Hyperthyroidism group is higher than subclinical hyperthyroidism group and the control group. The level of ET of subclinical Hyperthyroidism group is higher than the control group(P<0.05). The level of Hcy of Hyperthyroidism group and subclinical Hyperthyroidism group was lower than the control group(P<0.05). The level of TG, TC, LDL, LPa of subclinical Hyperthyroidism group are lower than the control group(P<0.05). The level of TG, TC, HDL, LDL, LPa of Hyperthyroidism group are lower than the control group and subclinical hyperthyroidism group (P<0.05). [Conclusions] All of ET, Hcy and lipids participate in the occurrence and development process of hyperthyroidism and subclinical hyperthyroidism. Monitoring the change of related indexes is helpful to predict the transformation of subclinical hyperthyroidism to hyperthyroidism and the occurrence of cardiovascular disease