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- 2019
MCC950 directly targets the NLRP3 ATP-hydrolysis motif for inflammasome inhibitionDOI: https://doi.org/10.1038/s41589-019-0277-7 Abstract: Inhibition of the NLRP3 inflammasome is a promising strategy for the development of new treatments for inflammatory diseases. MCC950 is a potent and specific small-molecule inhibitor of the NLRP3 pathway, but its molecular target is not defined. Here, we show that MCC950 directly interacts with the Walker B motif within the NLRP3 NACHT domain, thereby blocking ATP hydrolysis and inhibiting NLRP3 activation and inflammasome formation
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