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- 2019
CD40 Ligand-Modified Chimeric Antigen Receptor T Cells Enhance Antitumor Function by Eliciting an Endogenous Antitumor ResponseDOI: https://doi.org/10.1016/j.ccell.2019.02.006 Abstract: ? CD40L + CAR T cells kill antigen-negative tumor cells through CD40/CD40L interactions ? CD40L + CAR T cells improve antitumor response compared with second-generation CAR T cells ? CD40L + CAR T cells license APCs in vivo to aid in antitumor response ? Licensed APCs prime non-CAR T cells to recognize tumor cells and produce cytokine
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