DNA Replication Vulnerabilities Render Ovarian Cancer Cells Sensitive to Poly(ADP-Ribose) Glycohydrolase Inhibitors

？ Ovarian cancer cells show differential sensitivity to PARP and PARG inhibitors ？ PARG inhibitor sensitivity is due to an underlying DNA replication vulnerability ？ PARG inhibition blocks fork restart leading to persistent replication stress ？ PARG inhibition sensitizes cells to drugs targeting the CHK1 kinas