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- 2019
The Direct Molecular Target for Imipridone ONC201 Is Finally EstablishedDOI: https://doi.org/10.1016/j.ccell.2019.04.010 Abstract: In this issue of Cancer Cell, Ishizawa et al. describe the hyperactivation of ClpP as a strategy in cancer therapy. They discovered ONC201, a clinical-stage compound, as a potent activator of ClpP and established that ClpP activation is responsible for the antitumor activity of imipridone ONC201
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