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- 2019
A Platform of Synthetic Lethal Gene Interaction Networks Reveals that the GNAQ Uveal Melanoma Oncogene Controls the Hippo Pathway through FAKDOI: https://doi.org/10.1016/j.ccell.2019.01.009 Abstract: ？ Innovative bioinformatics pipeline reveals FAK as candidate synthetic lethal with Gαq ？ FAK is a central mediator of the GNAQ-driven oncogenic signaling circuitry ？ FAK activates YAP by MOB1 phosphorylation resulting in Hippo pathway inhibition ？ FAK represents a potential precision therapeutic target for uveal melanoma treatmen
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