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- 2019
Mitochondrial ClpP-Mediated Proteolysis Induces Selective Cancer Cell LethalityDOI: https://doi.org/10.1016/j.ccell.2019.03.014 Abstract: ？ Activation of the mitochondrial ClpP induces p53-independent cancer cell lethality ？ Imipridones are allosteric agonists of ClpP, being tested in human clinical trials ？ ClpP activation increases proteolysis of mitochondrial proteins ？ ClpP-mediated mitochondrial proteolysis impairs mitochondrial respiratory functio
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