Pervasive H3K27 Acetylation Leads to ERV Expression and a Therapeutic Vulnerability in H3K27M Gliomas

？ H3K27M mutant gliomas exhibit an enhancer landscape reflecting lineage of origin ？ Elevated H3K27 acetylation is pervasively distributed across the epigenome ？ Repeat element expression is de-repressed by H3K27M mutation ？ H3K27M cells are more vulnerable to DNA demethylation triggering viral mimicr