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- 2019
Targeting the Vulnerability of Glutathione Metabolism in ARID1A-Deficient CancersDOI: https://doi.org/10.1016/j.ccell.2018.12.009 Abstract: ？ ARID1A maintains GSH homeostasis by enhancing SLC7A11 transcription ？ Low SLC7A11 expression causes low basal GSH levels in ARID1A-deficient cancer cells ？ Inhibiting GSH/GCLC in ARID1A-deficient cancer cells causes apoptosis by ROS ？ GCLC is a druggable synthetic lethal target for ARID1A-deficient cance
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