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-  2019 

p53 Is a Master Regulator of Proteostasis in SMARCB1-Deficient Malignant Rhabdoid Tumors

DOI: https://doi.org/10.1016/j.ccell.2019.01.006

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Abstract:

? Smarcb1-deficient mosaic GEM models recapitulate malignant rhabdoid tumors (MRTs) ? Autophagy and UPR are essential adaptive mechanisms to proteotoxic stress in MRTs ? The MYC-p53 axis regulates proteostasis in SMARCB1-deficient cells ? Autophagy and proteasome inhibitors achieve durable responses in MRT model

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