|
- 2019
p53 Is a Master Regulator of Proteostasis in SMARCB1-Deficient Malignant Rhabdoid TumorsDOI: https://doi.org/10.1016/j.ccell.2019.01.006 Abstract: ? Smarcb1-deficient mosaic GEM models recapitulate malignant rhabdoid tumors (MRTs) ? Autophagy and UPR are essential adaptive mechanisms to proteotoxic stress in MRTs ? The MYC-p53 axis regulates proteostasis in SMARCB1-deficient cells ? Autophagy and proteasome inhibitors achieve durable responses in MRT model
|