Structural and Functional Studies of the RBPJ-SHARP Complex Reveal a Conserved Corepressor Binding Site

？ The corepressor SHARP binds the transcription factor RBPJ in a bipartite manner ？ SHARP binds the BTD and CTD of RBPJ, using motifs analogous to other corepressors ？ Structure-based mutants affect RBPJ-SHARP complex formation in vitro and in cells ？ RBPJ mutants are defective in repression from Notch target genes in cell