Calcium Influx through Plasma-Membrane Nanoruptures Drives Axon Degeneration in a Model of Multiple Sclerosis

？ Cytoplasmic calcium accumulations predict axon degeneration in neuroinflammation ？ Release from the axoplasmic reticulum does not explain calcium accumulations ？ Calcium influx from the extracellular space drives axon degeneration ？ Nanoscale ruptures allow entry of calcium across the axonal plasma membran