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-  2019 

HCN2 Channels in Cholinergic Interneurons of Nucleus Accumbens Shell Regulate Depressive Behaviors

DOI: https://doi.org/10.1016/j.neuron.2018.12.018

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Abstract:

? ChI activity is decreased in NAc shell in mouse models of depression ? Inhibition of ChIs renders naive mice susceptible to stress ? Dysfunction of HCN2 channels underlies reduced ChI activity in depressive mice ? Enhancing ChI activity by chemogenetics or HCN2 overexpression rescues depressio

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