Mutational Signature Analysis Reveals NTHL1 Deficiency to Cause a Multi-tumor Phenotype

？ Biallelic germline NTHL1 mutations predispose to a multi-tumor syndrome ？ Biallelic germline NTHL1 mutation carriers are at risk for breast cancer ？ Tumors from NTHL1-deficient patients reveal a cross-cancer NTHL1-associated signature ？ Mutational signature analyses can assist to identify germline DNA repair defect