The CMG Helicase Bypasses DNA-Protein Cross-Links to Facilitate Their Repair

？ Replicative helicase CMG bypasses DNA-protein crosslinks on its translocation strand ？ RTEL1, an accessory helicase, facilitates bypass by unwinding DNA beyond the DPC ？ CMG slows after bypass, likely due to uncoupling from DNA synthesis ？ Bypass triggers DPC proteolysis and prevents accidental degradation of CM