Tricarboxylic Acid Cycle Activity and Remodeling of Glycerophosphocholine Lipids Support Cytokine Induction in Response to Fungal Patterns

？ The fungal surrogate zymosan decreases pyruvate and supports acetyl-CoA production ？ The expression of IL-10 and IL-23 depends on pyruvate dehydrogenase activity ？ Autocrine platelet-activating factor (PAF) reinforces IL-10 and IL-23 induction ？ Acetyl-CoA is the nexus linking PAF biosynthesis to energetic metabolis