A Murine Model of Chronic Lymphocytic Leukemia Based on B Cell-Restricted Expression of Sf3b1 Mutation and Atm Deletion

？ Sf3b1-K700E mutation impairs 3′ splice site selection and induces cellular senescence ？ Sf3b1-K700E mutation in combination with Atm deletion causes CLL ？ CLL cells show genome instability and dysregulated BCR signaling ？ Human CLL cells with SF3B1 mutations show dysregulation of BCR signalin