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- 2019
Wild-Type p53 Promotes Cancer Metabolic Switch by Inducing PUMA-Dependent Suppression of Oxidative PhosphorylationDOI: https://doi.org/10.1016/j.ccell.2018.12.012 Abstract: ？ WTp53-PUMA pathway drives cancer metabolic switch ？ PUMA suppresses mitochondrial pyruvate uptake by inactivating MPC ？ IKKβ-mediated phosphorylation of PUMA is important for PUMA-MPC interaction ？ High levels of PUMA in HCC are correlated with poor prognosis of HCC patient
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