Integration of Genomic and Transcriptional Features in Pancreatic Cancer Reveals Increased Cell Cycle Progression in Metastases

？ Higher cell cycle progression in PDAC metastases; increases with driver gene loss ？ Half of PDACs are hypoxic and are associated with subtypes and treatment response ？ Paired tumors show molecular conservation and Halstedian progression ？ Multiple PDACs arising in the same pancreas are intra-parenchymal metastase