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-  2019 

Endocardial Notch Signaling Promotes Cardiomyocyte Proliferation in the Regenerating Zebrafish Heart through Wnt Pathway Antagonism

DOI: https://doi.org/10.1016/j.celrep.2018.12.048

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Abstract:

? EC Notch signaling is required for regenerative cardiomyocyte proliferation. ? EC Notch augments expression of secreted Wnt antagonists notum1b and wif1. ? Hyperactivated Wnt signaling suppresses regenerative cardiomyocyte proliferation. ? Wnt inhibition boosts cardiomyocyte proliferation in EC Notch-suppressed hearts

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