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-  2019 

A Mast-Cell-Specific Receptor Mediates Neurogenic Inflammation and Pain

DOI: https://doi.org/10.1016/j.neuron.2019.01.012

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Abstract:

? The mast cell receptor Mrgprb2 is required for neurogenic inflammatory pain ? Substance P (SP) recruits immune cells via Mrgprb2 independent of the NK-1 receptor ? SP activation of Mrgprb2 and its human ortholog MRGPRX2 releases cytokines ? Mrgprb2/X2 is a target for treating pai

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