Genome-Scale CRISPR Screens Identify Human Pluripotency-Specific Genes

？ A universal and scalable genetic platform in hPSCs for general use across all lineages ？ Robust knockout efficiencies translate into high-performance screening at genome scale ？ Stem cell-specific components of TP53 and OCT4 genetic networks in hPSCs are identified ？ Validation of PMAIP1 and PAWR function in sensitivity to DNA damage or dissociatio