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- 2019
High-Complexity shRNA Libraries and PI3 Kinase Inhibition in Cancer: High-Fidelity Synthetic Lethality PredictionsDOI: https://doi.org/10.1016/j.celrep.2019.03.045 Abstract: ？ A leukemia platform allows for saturated shRNA-based synthetic lethality screens ？ High-complexity shRNA libraries enable lethality identification with high fidelity ？ Small molecule inhibitors and cancer cell lines confirm predicted lethality ？ PI3K inhibitors and vincristine synergize in in vivo preclinical mouse trial
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