CRISPR-Mediated Editing of the B Cell Receptor in Primary Human B Cells

？ Methods to perform Cas9-mediated gene editing in primary human B cells are reported ？ Homologous recombination was confirmed by sequencing, PCR, and restriction digest ？ Replacement of B cell receptor loci in primary human B cells was achieved ？ Reprogramming the antibody specificity of B cells could have clinical importanc