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- 2019
The Coagulation and Immune Systems Are Directly Linked through the Activation of Interleukin-1α by ThrombinDOI: https://doi.org/10.1016/j.immuni.2019.03.003 Abstract: ？ Mammalian IL-1α contains a highly conserved thrombin consensus site ？ Thrombin cleavage leads to IL-1α activation and shedding from the cell surface ？ Thrombin activates IL-1α after epidermal wounding and after acute platelet loss ？ Thrombin-cleaved IL-1α is also detected in humans during sepsi
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