“Deepening” Insight on Skin Aging and Anti-microbial Immunity

Skin aging is of considerable interest from various perspectives, ranging from aesthetics to cancer development. Zhang et al. (2019) Zhang L.J. Chen S.X. Guerrero-Juarez C.F. Li F. Tong Y. Liang Y. Liggins M. Chen X. Chen H. Li M. et al. Age-related loss of innate immune antimicrobial function of dermal fat is mediated by transforming growth factor beta. Immunity. 2019; 50 : 121-136.e5 Abstract Full Text Full Text PDF PubMed Google Scholar elucidate an immunological consequence of aging in the adipose layer of skin. Age-dependent increases in TGF-β signaling impair fibroblast adipogenic potential that results in impaired anti-bacterial host defense