A Long-Acting PYY3–36 Analog Mediates Robust Anorectic Efficacy with Minimal Emesis in Nonhuman Primates

？ The gut peptide PYY 3–36 reduces food intake but causes severe GI intolerability ？ Like in humans, shorter-acting PYY analogs cause emesis in obese rhesus macaques ？ mAb-cycPYY is a stable, NPY2R-selective analog with a slow infusion profile ？ This results in a markedly improved efficacy/emesis therapeutic window in rhesu