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OALib Journal期刊
ISSN: 2333-9721
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-  2019 

Activation of Anxiogenic Circuits Instigates Resistance to Diet-Induced Obesity via Increased Energy Expenditure

DOI: https://doi.org/10.1016/j.cmet.2018.12.018

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Abstract:

? Deletion of the Bdnf gene in Emx1-expressing neurons of the brain leads to leanness ? The Bdnf mutant displays elevated anxiety and impaired GABAergic transmission ? The leanness of the mutant is due to increased basal metabolism and thermogenesis ? Amygdalar BDNF re-expression reverses anxiety and metabolic phenotypes of the mutan

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