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OALib Journal期刊
ISSN: 2333-9721
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-  2019 

Glutamine Metabolism Regulates Proliferation and Lineage Allocation in Skeletal Stem Cells

DOI: https://doi.org/10.1016/j.cmet.2019.01.016

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Abstract:

? Skeletal stem cells increase glutamine metabolism during osteoblast differentiation ? Glutamine metabolism regulates osteoblast and adipocyte specification ? Mice unable to metabolize glutamine have less bone and increased marrow fat ? Amino acid transaminase-derived α-ketoglutarate is critical for SSC proliferatio

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