|
|
- 2019
Migraine-Associated TRESK Mutations Increase Neuronal Excitability through Alternative Translation Initiation and Inhibition of TREKDOI: https://doi.org/10.1016/j.neuron.2018.11.039 Abstract: ？ TRESK, a K 2P channel implicated in migraine, heteromerizes with TREK1 and TREK2 ？ Migraine-associated TRESK-MT mutant induces formation of two proteins: MT1 and MT2 ？ MT2 is produced by frameshift mutation-induced alternative translation initiation ？ MT2 inhibits TREK to increase neuronal excitability and induce a migraine phenotyp
|
