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-  2019 

Genetic Analysis Reveals AMPK Is Required to Support Tumor Growth in Murine Kras-Dependent Lung Cancer Models

DOI: https://doi.org/10.1016/j.cmet.2018.10.005

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Abstract:

? AMPK does not phenocopy the lung tumor-suppressor role of its activator LKB1 ? AMPK deletion reduces tumor burden in KrasG12D and Kras p53 ?/? lung cancer models ? AMPK is required during glucose deprivation to induce Tfeb and Tfe3 activation ? Tfe3 activity is required for growth of mouse lung tumor

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