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-  2019 

Lymphocyte-Derived Exosomal MicroRNAs Promote Pancreatic β Cell Death and May Contribute to Type 1 Diabetes Development

DOI: https://doi.org/10.1016/j.cmet.2018.09.011

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Abstract:

? T lymphocytes release exosomes containing specific microRNAs ? T lymphocyte exosomes can transfer microRNAs to rodent and human pancreatic β cells ? The transferred microRNAs trigger chemokine expression and apoptosis of β cells ? Blockade of microRNAs transferred in β cells decreases diabetes incidence in NOD mic

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