Combined Single-Cell Profiling of lncRNAs and Functional Screening Reveals that H19 Is Pivotal for Embryonic Hematopoietic Stem Cell Development

？ Single-cell transcriptome profiling constructs lncRNA landscape of HSC development ？ Computational and functional screening identifies 6 lncRNAs affecting hematopoiesis ？ Loss of H19 lncRNA results in failed HSC generation from endothelium in AGM region ？ H19 deficiency leads to promoter hypermethylation of Runx1 and Spi1 in pre-HSC