Unraveling the Paradox of Statins with Human Neurons: New Leads in Alzheimer’s Disease

Conflicting clinical studies have reported that statins both reduce and accelerate cognitive impairments in Alzheimer’s disease. In this issue, Van der Kant et al. (2019) Van der Kant R. Langness V. Herrera C. Williams D. Fong L. Leesstemaker Y. Steenvoorden E. Brouwers J. Helms J. Ovaa H. Giere M. Wagner S. Bang A. Goldstein L. Cholesterol Metabolism Is a Druggable Axis that Independently Regulates Tau and Amyloid-β in iPSC-Derived Alzheimer’s Disease Neurons. Cell Stem Cell. 2019; 24 ( this issue) : 363-375 Abstract Full Text Full Text PDF PubMed Scopus (1) Google Scholar use iPSC-derived neurons to thoroughly dissect the link between cholesterol synthesis, phospho-Tau, and amyloid-β, revealing new therapeutic opportunities in Alzheimer’s disease and related dementias