Spatiotemporal Resolution of SCF Supply in Early Hematopoiesis

Evidence suggests that hematopoietic progenitor cells self-replenish in situ over prolonged time frames, centering the question on the identity and source of growth factors maintaining HPC fidelity. In this issue of Cell Stem Cell, Comazzetto et al. (2019) Comazzetto S. Murphy M.M. Berto S. Jeffery E. Zhao Z. Morrison S.J. Restricted hematopoietic progenitors and erythropoiesis require SCF from leptin receptor+ niche cells in the bone marrow. Cell Stem Cell. 2019; 24 ( this issue) : 477-486 Abstract Full Text Full Text PDF PubMed Scopus (1) Google Scholar suggest that normal stem and progenitor function relies on stem cell factor provided by distinct cellular sources