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- 2019
Cholesterol Metabolism Is a Druggable Axis that Independently Regulates Tau and Amyloid-β in iPSC-Derived Alzheimer’s Disease NeuronsDOI: https://doi.org/10.1016/j.stem.2018.12.013 Abstract: ? Drug screening identifies inhibitors of aberrant phosphorylated Tau (pTau) accumulation ? Cholesteryl esters (CE) were identified as upstream regulators of pTau proteostasis ? The effects of CE on Tau proteostasis are correlated with, but independent of, APP and Aβ ? Lead compound enhance CE-dependent pTau proteasomal turnover specifically in neuron
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